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As a typical damage-associated molecular pattern (DAMP) molecule, HMGB1 can mediate heat stress-induced NLRP3 inflammasome activation via the TLR4 and receptor for advanced glycation end products (RAGE) signaling pathways, thereby promoting IL-1 activation and inducing hepatocyte pyroptosis, ultimately leading to severe liver injury in rats [26]

Fivenson EM, Lautrup S, Sun N, Scheibye-Knudsen M, Stevnsner T, Nilsen H, et al

JAMA network open, 3(1), e1919274

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Among those team members were co-first authors Shanshan Liu, a postdoc in the lab who has long researched mitochondrial metabolism, and Mark Gad, a Ph.D student jointly supervised by Birsoy and Richard Hite, of Memorial Sloan Kettering Cancer Center

Boosts Immunity and Metabolism: My12 Plus Injection strengthens the immune system and improves metabolism, allowing better nutrient utilization and overall vitality